Research Associate I, Preclinical Sciences

About Notch (www.notchtx.com)

Notch is an early-stage biotech company, working to maximize the benefit of cell therapies through a proprietary T cell-production platform which combines sophisticated product design with commercial-compatible processes to enhance patient outcomes. Notch s iPSC-based technology platform allows for precision control of notch signaling, which removes several critical limiting factors in the development of cell therapies, delivering the ability to design and manufacture a uniform and unlimited supply of therapeutic T cells.

Role Summary:

The candidate will be in a role that will support discovery research by interfacing with Cancer Biology and Cell Engineering groups of Notch in Seattle. This individual will be responsible for advancing Notch s discovery pipeline by performing experiments within the cancer biology group while working closely with other members of the cell therapy team in Seattle.

Key responsibilities:

• Mammalian cell culture: working with adherent and suspension cell culture, including primary immune cells, and cryopreservation
• Perform routine in vitro immunological assays such as flow cytometry, ELISA/MSD, and cytotoxicity analysis.
• Design and execute assays to phenotype T cells following antigen specific T cell activation.
• Engineer, expand, and maintain primary immune cells and cell lines.
• Support in vitro assay development. Analyze and present experimental data to our internal team and collaborators.
• Be a good lab citizen by sharing in lab responsibilities to maintain a well-functioning lab.
• Comply with standard laboratory practices and company policies, including documentation and maintenance of electronic lab notebook and contribute to support documentation.
• Proactively recognize and solve technical and scientific issues to assure high quality data.

Qualifications and role requirements:

• S.in Biology, Immunology, Biochemistry, Molecular biology or related field with 0-2 years research experience in academia or industry.
• Experience with primary T cell culture and in vitro assays is desirable.
• Robust knowledge of CAR and/or engineered T cell signaling is a plus.
• Experience with standard immunological assays, including multi-color flow cytometry, and MSD.
• Working knowledge of various software (e.g. FlowJo, GraphPad Prism, FACSDiva).
• Passionate, self-motivated, collaborative, and determined to do great science.
• Highly organized and scientifically rigorous with significant attention to detail.
• Demonstrated ability to work and think independently.
• Working safely on a predictable and regular in-person basis is an essential job function for this position.

Desired characteristics and preferred skills:

• Demonstrated ability and keen interest in modelling Notch s Core Values: Collaborative, Motivated, Ingenious.
• Highly flexible and positive working attitude.

Salary Range: $63,000 - $82,000

Benefits:

• Paid Vacation and Sick time
• Hybrid Work Framework
• Healthcare plans
• 401k/RRSP plan
• Commuting Financial Assistance
• Home Office WIFI Support
• Employee assistance programs (EAPs)
• Internal learning & development opportunities

Notch Therapeutics, Inc. is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, provincial or local law.

Requests for accommodation can be made at any stage of the recruitment process providing the applicant has met the Bona-fide requirements for the open position. Applicants need to make their requirements known when contacted.