Scientist III (Temporary)

About IGM Biosciences, Inc.

IGM Biosciences (Nasdaq: IGMS) is a clinical-stage biotechnology company committed to developing and delivering a new class of medicines to treat patients with autoimmune and inflammatory diseases. The Company’s pipeline of clinical and preclinical assets is based on the IgM antibody, which has 10 binding sites, compared to conventional IgG antibodies with only 2 binding sites. We have created unique IgM antibodies with high selectivity, affinity, and avidity that may redefine what is possible for therapeutic antibody medicines. We are committed to exploring how the unique structure and binding properties of the IGM antibody can improve outcomes for patients with these serious conditions. The Company also has an exclusive worldwide collaboration agreement with Sanofi to create, develop, manufacture, and commercialize IgM antibody agonists against oncology, immunology, and inflammation targets. For more information, please visit www.igmbio.com.

Imvotamab in Autoimmune and Inflammatory Diseases

Imvotamab is a bispecific T cell engaging IgM antibody targeting CD20 and CD3 proteins. We believe that Imvotamab, with its 10 binding units for CD20, may successfully bind to CD20 expressing B cells with more power (avidity) compared to an IgG bispecific antibody with only one or two binding units for CD20. Our preclinical studies suggest that Imvotamab may offer the potential for deeper depletion of B cells, including those in low CD20 expressing cells, than currently approved antibody therapies. We are evaluating Imvotamab in Phase 1b clinical trials of Imvotamab in severe systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and idiopathic inflammatory myopathies (myositis).

Position:

We seek a highly motivated and innovative scientist with immunology research experience and a passion to develop antibody-based therapeutics. You will play an integral role in the pre-clinical development of novel autoimmunity and inflammation therapeutics. The ideal candidate will have a proven track record of experience with core immunological assays and models (e.g., T cell proliferation, antigen recall, in vivo models of inflammatory disease) and techniques (immune cell culture, flow cytometry, ELISA, RT-PCR, etc.) The candidate will be required to coordinate and execute on research projects across multiple functional teams, both internal of IGMS and external vendors and collaborators. Strong communication skills and organizational skills are essential. A key initial responsibility will be the set up and establishment of core capabilities in the AI lab. This role involves delivering on programs through proof- of-concept in vitro and in vivo studies and advancing therapeutic candidates from early discovery to IND- enabling studies.

Responsibilities:

• Establish core capabilities in AI lab
• Lead research efforts to generate proof-of-concept in vitro and in vivo data for early-stage autoimmune and inflammation programs
• Lead therapeutic candidate selection and perform IND-enabling studies
• Work closely with team members and CROs to develop assays and models to assess biological activity
• Present results at internal and external meetings
  
  
  

Qualifications:

• Ph.D. with 2-7 years of industry experience or with equivalent postdoctoral research experience or a Bachelor’s/ Master’s degree with 10+ years of industry experience in the field of immunology.
• Must have hands-on experience and proficiency in one or more of the following areas: multi-color flow cytometry, complex cell-based functional assays, in vivo mouse models of disease.
• Must be proficient with Microsoft Word, Excel, and PowerPoint, GraphPad Prism, and FlowJo
• Experience establishing mechanistic in vitro and ex vivo immune cell-based assays with primary immune cells from human and relevant animal species.
• Understanding of and ability to select relevant in vivo models for mechanistic and efficacy studies.
• Demonstrated track record of independence, critical thinking, and scientific research achievements in immunology and/or significant contributions to a discovery program or therapeutic development.
• Highly organized with reliable time-keeping skills and able to maintain a detailed and wellorganized electronic notebook.
• Must have strong interpersonal, collaboration, and communication skills.
• Being a team player and respectful of others is a must.
• Able to thrive in a fast-paced, start-up environment.
• Able to commute to Doylestown.