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Postdoctoral Scientist, In vivo Oncology (Onsite)
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Be a part of the legacy: Postdoctoral Research Fellow Program
Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
The In Vivo Pharmacology - Oncology group within the Department of Quantitative Biosciences (QB) is seeking a Post Doctoral Fellow with expertise in cancer biology to join our Boston-based Exploratory Discovery team. The successful candidate will have a track record of creative and innovative research, demonstrated through peer-reviewed publications. They will be able to work independently but is also expected to proactively collaborate with colleagues across multiple disciplines. The successful candidate will have a strong interest in mechanisms of oncology drug resistance and minimal residual disease. Primary responsibilities will include designing and executing in vivo and ex vivo preclinical studies to characterize tumor microenvironment (TME) interactions pertaining to antibody-drug conjugate (ADC) resistance and tumor relapse. The candidate will present their data at internal and external conferences as well as publish their findings in a peer-reviewed journal . The candidate will be an active participant in the positive and critical scientific dialogue that is necessary to progress our oncology drug discovery programs. An ability to communicate clearly and collaborate effectively with colleagues from multiple different disciplines will be essential for success.
Responsibilities:
Required experience and skills:
Education Requirements:
PhD in the field of cancer biology, molecular biology, or similar discipline.
PostdoctoralOpportunities
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
Pay Transparency Nondiscrimination
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
No Travel Required
Flexible Work Arrangements:
Not Applicable
Shift:
Not Indicated
Valid Driving License:
No
Hazardous Material(s):
NA
Job Posting End Date:
10/30/2024
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID:R316976
Be a part of the legacy: Postdoctoral Research Fellow Program
Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
The In Vivo Pharmacology - Oncology group within the Department of Quantitative Biosciences (QB) is seeking a Post Doctoral Fellow with expertise in cancer biology to join our Boston-based Exploratory Discovery team. The successful candidate will have a track record of creative and innovative research, demonstrated through peer-reviewed publications. They will be able to work independently but is also expected to proactively collaborate with colleagues across multiple disciplines. The successful candidate will have a strong interest in mechanisms of oncology drug resistance and minimal residual disease. Primary responsibilities will include designing and executing in vivo and ex vivo preclinical studies to characterize tumor microenvironment (TME) interactions pertaining to antibody-drug conjugate (ADC) resistance and tumor relapse. The candidate will present their data at internal and external conferences as well as publish their findings in a peer-reviewed journal . The candidate will be an active participant in the positive and critical scientific dialogue that is necessary to progress our oncology drug discovery programs. An ability to communicate clearly and collaborate effectively with colleagues from multiple different disciplines will be essential for success.
Responsibilities:
- Assessing the mechanisms of action of antibody drug conjugates using in vivo preclinical mouse models and ex vivo assays, primarily the TME interactions impacting ADC efficacy and resistance.
- Harvesting and analyzing samples collected in preclinical in vivo studies to identify biomarkers in blood, tumors, and surrogate tissues using molecular methods including but not limited to: multiplexed immunohistochemistry (IHC), imaging mass cytometry, single cell sequencing, flow or mass cytometry and in vitro immunoassays.
- Independently plan and execute studies with the primary goal of presenting data at external conferences and publishing data, ideally in a high impact journal.
- Communicate and present data clearly and concisely to the appropriate teams and stakeholders.
- Be able to thrive in a team environment.
Required experience and skills:
- Extensive expertise with oncology models is desired (in vitro tissue culture and in vivo models). Experience with in vitro tumoroid/organoid culture would be a plus.
- Experience with multiplexed IHC, molecular biology techniques and data analyses tools; single cell RNA sequencing and flow cytometry is desired. Experience using spatial transcriptomics is a plus.
- Some experience designing and executing in vivo animal studies including animal handling and dosing, blood and tissue sampling and data collection analysis and interpretation is desired.
- Demonstrated ability to function and communicate effectively in a multi-disciplinary environment.
- Excellent problem-solving, communication, and project management skills.
Education Requirements:
PhD in the field of cancer biology, molecular biology, or similar discipline.
PostdoctoralOpportunities
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
Pay Transparency Nondiscrimination
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
No Travel Required
Flexible Work Arrangements:
Not Applicable
Shift:
Not Indicated
Valid Driving License:
No
Hazardous Material(s):
NA
Job Posting End Date:
10/30/2024
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID:R316976
Employers have access to artificial intelligence language tools (“AI”) that help generate and enhance job descriptions and AI may have been used to create this description. The position description has been reviewed for accuracy and Dice believes it to correctly reflect the job opportunity.
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